Lentiviral self-inactivating vectors are the retroviral vectors with the greatest potential for gene therapy Nondividing cells can be transduced by lentiviral vectors. They possess a low ...

These findings raise the question of whether retroviral VEGF gene therapy is useful for therapeutic ‘angiogenesis’ without risking ‘angioma-genesis’. Overexpression of VEGF may lead to an ...

The “bottleneck” of current gene therapy approaches is the lack of an efficient gene delivery system. Retroviral vectors have been very useful for ex vivo gene delivery, but suffer two major ...

They can provide stable, long-term gene expression but can only infect dividing cells. Retroviral vectors, such as those based on murine leukemia virus (MLV), have been used in gene therapy clinical ...

Retroviruses, adenoviruses, and herpes viruses have been studied as vectors for cancer gene-therapy. Retroviruses are single-stranded RNA viruses that ... it integrates into the host genome and ...

Clinical gene therapy began with the introduction via a retroviral vector of the gene encoding adenosine deaminase into the ... In haemophilia B, adeno-associated viral vectors expressing human factor ...

driven by improved tools and deeper understanding of the diseases gene therapy aims to treat. A key example is the evolution of delivery vectors. The first generation relied heavily on wild-type adeno ...

Rizvi is involved in studying molecular steps in the replication of retroviruses such as human, simian, and feline immunodeficiency viruses (HIV, SIV, & FIV), Mason–Pfizer monkey virus, and mouse ...

Vector production (clinical-grade plasmid DNA and retroviral vectors). Research and development work relating to vector production and transduction of patient cells. Molecular analysis of gene ...