To Jubao Duan of the University of Chicago, the authors provide compelling evidence. That tau dysregulation derails lipid droplets “provides novel mechanistic insight into how accumulation of human ...

【导读】氧化应激（OS）与重度抑郁症（MDD）的病理生理学密切相关，但分子机制在很大程度上仍然未知。本研究的目的是确定与OS和MDD相关的基因，并进一步评估这些基因作为诊断标志物和潜在治疗靶点的效用。2024年10月19日，中国医科大学附属第一医院朱 ...

Oxidant stress is recognized to have a central role in the development and progression of myocardial dysfunction—but the molecular targets of reactive oxidative species (ROS) remain obscure.

2011年，芝加哥大学赵英明教授团队首次发现了赖氨酸琥珀酰化（Lysine ...

Mitochondrial function plays a pivotal role in maintaining cellular energy production and regulating oxidative stress. In ...

Researchers are constantly studying the impact of various compounds on the epidermal layer, seeking to isolate compounds that ...

但是，关于线粒体如何调控铁死亡的具体仍然未知。 近日，来自美国阿尔伯特-爱因斯坦医学院的Richard N. Kitsis在Molecular Cell上发表了论文OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress ...

Infertility is often seen as a women's issue, but male factor infertility affects nearly half of couples. It's time to break ...

氧化应激是肌肤炎性衰老的重要因素之一，环境因素如紫外线辐射、空气污染等，会促进肌肤炎性衰老。体内自由基的产生与抗氧化系统的失衡，会导致氧化损伤并引发炎症反应。活性氧（ROS）可以激活核因子κB（NF-κB）等炎症信号通路，促进炎症因子的释放，如白细胞 ...

A recent study highlights the hepatotoxicity of tire-wear particle (TWP) leachates in aquatic environments, impacting ...

The overproduction or chronic production of reactive oxygen species can cause inflammatory reactions, tissue changes and DNA, protein and lipid damage. Nanoparticles also cause mechanical damage ...