They also share regulators of their activity: the transcriptional activity of both FoxO and p53 is controlled by the deacetylase SIRT1, the deubiquitylating enzyme USP7 and the serine–threonine ...

The NAD +-dependent histone deacetylase Sir2 has a crucial role in heterochromatin formation in budding yeast by stabilizing rDNA and thereby extending lifespan. DNA damage and increased rDNA ...

This is the first comprehensive immunohistochemical analysis of the expression of several class I HDAC proteins (1, 2 and 3) in urothelial carcinoma. In our study, we found all three isoforms in a ...

Background: Histone deacetylases (HDACs) are known to be associated with an overexpression in different types of cancer such as colon and prostate cancer. In this study we aimed to evaluate the ...