He recommends letting frozen grapes melt in your mouth. “The cold temperature activates TRPM8 receptors in the mouth, which ...

Peripheral or central activation of the TRPM8 (transient receptor potential melastatine family member 8) cool-sensitive ion channel can produce an analgesic effect, reversing hypersensitivity and ...

Data from Trpm8-knockout mice have suggested that a single receptor, transient receptor potential melastatin 8 (TRPM8), is involved in the perception of these different types of cold sensation.

Aerie has also said it thinks TRPM8 receptor agonist AR-15512 has the potential to become a best-in-class agent for patients with dry eye disease, working to increase the production of tears as ...