However, somatic cells have little or no telomerase activity, gradually resulting in telomere attrition and cellular aging. Telomere length (TL) varies among individuals but steadily declines with ...

Figure 2: Replicative ageing causes histone loss in yeast and human fibroblasts. In the search for a mechanism by which increased population doubling and telomere attrition may cause the loss of ...

However, as cells divide, these telomeres shorten, ultimately leading to cellular aging and dysfunction. This connection between telomere length and aging has made them a focal point in longevity ...

RPA is a heterotrimeric protein complex (RPA1/2/3) that binds to DNA and is involved in genome replication and repair, and potentially in telomere replication. These patients also showed abnormally ...

Dr. Sajad Zalzala, chief medical officer of AgelessRx in Michigan, helps people live their longest, healthiest lives. He ...

Infectious and non-infectious respiratory diseases are regarded as accelerated-age conditions in which chronic inflammation, exacerbated/dysregulated immune responses, and immunological senescence ...

Caption The hallmarks of aging, such as mitochondrial dysfunction and telomere attrition, contribute to an increased risk of Alzheimer's disease and other neurological conditions. Rapamycin and ...

Blackburn spoke to us about why this is, and how we can take better care of our telomeres to slow down the effects of aging. Blackburn co-authored "The Telomere Effect: A Revolutionary Approach to ...