However, somatic cells have little or no telomerase activity, gradually resulting in telomere attrition and cellular aging. Telomere length (TL) varies among individuals but steadily declines with ...

Dr. Sajad Zalzala, chief medical officer of AgelessRx in Michigan, helps people live their longest, healthiest lives. He ...

2. Telomere attrition: Shorter telomeres (DNA sequences at the end of a chromosome) are what cause visible aging signs like wrinkles and slower cell regeneration. 3. Epigenetic alteration ...

However, as cells divide, these telomeres shorten, ultimately leading to cellular aging and dysfunction. This connection between telomere length and aging has made them a focal point in longevity ...

Blackburn spoke to us about why this is, and how we can take better care of our telomeres to slow down the effects of aging. Blackburn co-authored "The Telomere Effect: A Revolutionary Approach to ...

Caption The hallmarks of aging, such as mitochondrial dysfunction and telomere attrition, contribute to an increased risk of Alzheimer's disease and other neurological conditions. Rapamycin and ...

Aging is a universal and complex process affecting all organisms, characterized by several genetic hallmarks such as telomere ...

In 2013, Carlos López-Otín of the Instituto Universitario de Oncología (IUOPA) in Spain published a paper on the nine hallmarks of aging: genomic instability, telomere attrition, epigenetic ...

Furthermore, telomere shortening due to the inability of the DNA-replication machinery to fully replicate the ends is a critical mechanism of tumor suppression as well as a hallmark of aging.