The larger macronucleus, which is responsible for programming most of the ... the telomere through the RNA template, and it then catalyzes the extension of the G-tail. Only one extension cycle ...

The main role of the telomere bouquet was thought to be the promotion of recombination, but Tomita and Cooper now report in Cell that, in fission yeast, the telomere bouquet has a crucial role in ...

Telomeres are specialized nucleoprotein structures at the ends of eukaryotic chromosomes that are essential for chromosome stability and cellular proliferation. Telomeric DNA does not encode for ...

The Arnoult lab focuses on genome stability, DNA repair and telomere biology. We study the different types of pathways that cells use to repair DNA double strand breaks, and how telomeres escape these ...

an enzyme that prevents telomere shortening as cells divide and is known to promote cancer, also protects against malignant transformations in a key stage at the end of a cell's life.

Having determined how telomerase is recruited, scientists were left with a fundamental question: how does CST–Polα/primase ...

Genomic instability occurs due to oxidative stress, epigenetic alterations, inadequate DNA repair, and telomere maintenance. Throughout the cell cycle, magnesium is essential for stabilizing chromatin ...