AlphaFold2这类系统的出现给AI工业界引入一种工程化门槛，在这个工程化门槛之下的AI模型，只要论文公开，大家就能去应用；在这个工程化门槛之上的AI系统，即使论文公开代码开源，绝大多数团队连去复现源版系统性能的AI工程化能力都没有。

In fact, each gene in cellular DNA contains the code for a unique protein structure. Not only are these proteins assembled with different amino acid sequences, but they also are held together by ...

Protein folding is the process by which proteins achieve their mature functional (native) tertiary structure, and often begins co-translationally. Protein folding requires chaperones and often ...

The polypeptide chain in these secondary structures then folds to produce the overall 3D tertiary structure. Once correctly folded, the protein can undergo further maturation through different ...

Proteins have four levels of structure: primary (amino acid sequence), secondary (local folding patterns like alpha helices and beta sheets), tertiary (overall 3D shape), and quaternary (assembly of ...

The sequence of amino acids in the chain determines how the chain will fold up to make the protein, so different proteins have different three-dimensional shapes. The three-dimensional shape of a ...

That structure is essential for the protein's function. Typically, figuring out the structure involves laborious biochemistry to purify the protein, followed by a number of imaging techniques to ...

Proteins perform wide variety of tasks in the living organisms. Their ability to perform the designated tasks depends critically on their tertiary structure, achieved as a result of folding. But how ...

David Baker, Demis Hassabis and John M. Jumper revealed how amino acids shape protein structure, a finding that could aid in drug discovery Margherita Bassi Daily Correspondent David Baker ...

Efforts to unlock the mysteries of proteins, building blocks of life, have earned three scientists the 2024 Nobel Prize in chemistry. The prize goes to David Baker “for computational protein ...

The prize winners are projected on a screen in Stockholm on Wednesday above. Sitting, from left to right, are Johan Aqvist, member of the Nobel Committee for Chemistry; Hans Ellegren, permanent ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...