The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...

Factors found to be amplified in human tumors are indicated in green and those found to be frequently lost are indicated in red. Black lines indicate direct activation (arrowheads) or inhibition ...

Dysregulated cell signaling underlies various diseases, emphasizing the importance of understanding these pathways for ...

Newly discovered estrogen receptor-dependent signaling ... The MAP kinase family includes the extracellular-signal related kinases (ERKs), which signal through a pathway involving sequential ...

Tyrosine kinase inhibitors (TKIs) are a class of targeted cancer therapies designed to block the action of tyrosine kinases, enzymes that play a key role in cellular functions such as growth, division ...

Since kinases drive numerous signaling pathways in biology (both normal and disease), determining ... This system utilizes a high content peptide microarray containing phosphorylatable tyrosine (PTK ...

Baylor College of Medicine has disclosed proteolysis targeting chimeras (PROTACs) comprising cereblon (CRBN) ligands coupled to Bruton tyrosine kinase (BTK)-, DNA-binding protein Ikaros (IKZF1)- and ...

As a non-receptor tyrosine kinase, TYK2 is a member of the JAK kinase family, which is an important kinase on the JAK-STAT signaling pathway and plays an important role in the pathogenesis of ...

Preliminary data from the first-in-human study presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting demonstrated that CS5001 is well-tolerated and exhibits encouraging ...

His research focuses on elucidating the role of receptor tyrosine kinase in the invasion and survival of glioblastoma (GBM). He is also interested in exploring the interplay between kinase signaling ...

NEU-111 is a potent and highly selective oral allosteric inhibitor of tyrosine kinase 2 (TYK2), a JAK ... as a critical modulator of immune signaling pathways. Importantly, we see significant ...