We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog, TGFβ (transforming growth factor-β)–BMP (bone morphogenetic protein) and receptor tyrosine kinases ...

The researchers discovered that the E2F1 and E2F4 transcription factors induce the expression of WNT ligands, such as WNT7A, WNT7B, WNT10A, and WNT4, while the pRb and RBL2 proteins act to reduce ...

Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation and increased fracture risk. In vitro studies showed that inflammation induces bone erosion and inhibits bone ...