Alternatively, an inhibitor might suffer a loss-of-function mutation, lose its ability to regulate signalling and lose its functions as a tumour suppressor. Both types of change in Wnt signalling ...

Type 2 diabetes (T2D) and obesity (OB) are associated with chronic low-grade inflammation and increased fracture risk. In vitro studies showed that inflammation induces bone erosion and inhibits bone ...

The requirement for canonical Wnt/β-catenin signaling in Hh-driven BCC development is increasingly recognized. Forkhead box genes may represent important players in the signaling downstream of Hh ...

Cite this: TNF Signaling Inhibition in the CNS: Implications for Normal Brain Function and Neurodegenerative Disease - Medscape - Oct 17, 2008.