Conditional gene targeting based on excision or inversion ... recombination from the Cre-ERT2 transgene 29 leads to death of c-Myc-driven primary B cell lymphomas. Taken together, these ...

In parallel with the hunt to identify MYC target genes and their mechanisms of regulation, there was an equally voracious appetite to identify and understand the main biological activity and ...

As Shift Bioscience raises $16 million in seed funding, delve into the field of cellular reprogramming to tackle age-related ...

The paper is titled, "A recurrent de novo MAX p.Arg60Gln variant causes a syndromic overgrowth disorder through differential expression of c-Myc target genes." The individuals share some other ...

28 in Nature Communications identifies the MYC gene as a common denominator across ... strengthen the evidence that MYC may be a critical target for prostate cancer treatment or prevention ...

“You just can’t reduce something as complex as human exploration to a single gene,” he says, laughing. “Genetics doesn’t work that way.” Fortunately for me, I had to wander only a ...

Clin. Invest. 10.1172/JCI133737 (2020). PMID: 31917687 Andre Catic, M.D., Ph.D. The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes.

Gene-expression-based analyses reflect neuroblastoma tumor behavior and may accurately predict patient outcome. Global genomic pattern and gene-expression-based classifiers will replace current ...

This breakthrough finding revealed a long-postulated ... Noninvasive Measurement of Gene Expression at Target Locations in the Brain Aug. 7, 2024 — Bioengineers have developed a noninvasive tool ...

Vital research findings pointing to improved treatment for children with Group 3 medulloblastoma brain tumors have been ...

Researchers have identified a critical variation in medulloblastomas, a form of brain cancer in children. Their discovery of ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...