Indeed, like CDK1, CDK5 is also a canonical cell-division-cycle CDK. We have established the role of CDK5 in cell division in non-cancer cells, but the CDK5–cyclin B1 complex might have an even ...

Recent work has discovered the role of the cyclin-dependent kinase (CDK)-binding protein Cks1 in degrading the CDK inhibitor p27 Kip1. This process is essential for DNA replication and is ...