Second, SCoV2 activates EGFR-mediated cell survival signaling and subsequently promotes mitochondrial EGFR internalization, which contributes to the maintenance of abnormal mitochondrial ...

Petosemtamab 1500 mg monotherapy phase 2 interim data continues to demonstrate clinically meaningful activity in 2L+ HNSCC – Conference call on Saturday, Dec. 7 at 9:00 a.m. ET to discuss full data ...

When complex multicellular organisms grow and develop, their tissues must undergo remodeling. As new cells begin to ...

SOS1 is a guanine nucleotide exchange factor (GEF) that activates KRAS, and recent preclinical studies have demonstrated that combining KRAS and EGFR inhibitors with SOS1 inhibitors can overcome ...

A preliminary overall response rate (ORR) of 42% was seen in 19 patients with known osimertinib resistance EGFR mutations (either ... and suppresses EGFR signaling in patient tumors at the 19th ...

and novel agents (e.g. tirapazamine, EGFR inhibitors and other targeted agents) with radiotherapy will be examined. This article is part one of two articles. In the subsequent article, the general ...

EGFR is responsible for cancer cell survival and proliferation, and TGF-b signaling has immunosuppressive effects within the tumor microenvironment, or TME. The company says in its S-1 that it ...

EpiBiologics, a leader in tissue-selective extracellular protein degradation, will be presenting new data demonstrating the unique capabilities of its ...

They also discovered that the virus manipulates the EGFR protein, which is critical for cellular growth signaling, to ...