本土小核酸药物研发：“蓝海”与“蓝图”
北京时间10月7日，瑞典卡罗琳斯卡医学院宣布，将2024年诺贝尔生理学或医学奖授予美国科学家维克托·安布罗斯(Victor Ambros)和加里·鲁夫坎(Gary Ruvkun)，以表彰他们发现了微小核糖核酸（microRNA，以下简称miRNA）及其在转录后基因调控中的作用。 众所周知，在新药蓬勃发展的今天，小核酸药物被认为是将带来“除小分子药和抗体药之外的第三次制药浪潮”的关键。随着诺贝尔奖花 ...
Nature4 年
Nanjing School: Extracellular microRNA mediates co-evolution between species
The work on secreted miRNA has led to extracellular vesicle-based delivery of small interfering RNA (siRNA) therapy. This white paper describes research undertaken by groups at SLiS of NJU ...
pharmaphorum3 年
Cash round sets up trial of InteRNA’s microRNA for cancer
MicroRNAs are smaller than the small interfering RNA (siRNA) drugs now reaching the ... INT-1B3 is a chemically modified mimic of a microRNA called miR-193a-3p that is formulated in lipid ...