Ben Hargreaves speaks to Liberate Bio, a company that is hoping to address the delivery issues that could prevent mRNA, as well as siRNA and ASO therapeutics, from reaching their full potential ...

LMU researchers have investigated how cationic polymers organize on a molecular level when transporting RNA drugs.

The siRNA antisense strand guides RISC to the target mRNA, resulting in endonucleolytic cleavage. Important features in designing siRNA are specific target recognition and minimization of off ...

The exogenous RNA is digested in to small interfering RNAs (siRNA), which bind a nuclease complex to form an RNA-induced silencing complex. This complex targets the endogenous gene transcripts by base ...

See how small bits of non-coding RNA target mRNA for destruction and regulate gene expression. Evidence has also shown that siRNA is involved in antiviral defense in certain plant and animal species.

Materials & Methods: The NDS consisted of cationic liposomes (carrier, 100–140 nm), doxorubicin (DOX, anticancer drug), siRNA targeted to MRP1 and BCL2 mRNA (suppressors of pump and nonpump ...