Pericytes regulate vascular constriction. Within the brain-wide perivascular space, a polarized astrocyte phenotype with AQP4 expression is essential for the functioning of the glymphatic system.
The possible link between neuroinflammation and AQP4 was advertised with neuromyelitis optica (NMO), a demyelinating disease. NMO is a pathological condition characterized by abnormal signals most ...
As reviewed, AQP4 has a key role in the edema process, which may be followed by ADC changes in different brain pathologies. However, whether the presence of AQP4 is beneficial or detrimental seem ...