The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.orglett.4c04114.

Lipid nanoparticles made from lipids optimized via directed chemical evolution show high performance as mRNA delivery vehicles.

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids—key ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acs.joc.4c02442.

Engineers have cooked up a new way to improve mRNA delivery, developing an optimal 'recipe' for ionizable lipids -- key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...

Scientists from the University of Pennsylvania have developed an ideal “recipe” for ionizable lipids, which are essential ...

To enhance mRNA distribution, Penn engineers have created an ideal “recipe” for ionizable lipids, which are essential ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal “recipe” for ionizable lipids — key ...

Natural gas is a fossil fuel that is widely used in the U.S. for heating, cooking, and electricity generation, and it is also ...

A crucial contributor to the team's recipe for improved ionizable lipids is A 3 coupling, a three-component reaction named for its chemical ingredients: an amine, an aldehyde and an alkyne. The ...