RNA splicing is a modification of the nascent ... into the regulatory mechanisms and therapeutic applications of alternative splicing. Interpreting the significance of putative splice-altering ...

By knocking down the expression of 305 spliceosome components and regulators in human cancer cells and employing deep RNA sequencing, the researchers monitored over 250,000 alternative splicing events ...

Dr. Silvi Rouskin's lab. Our research focuses on alternative RNA structures and the myriad of roles they have in both viral and human biology. Our lab is interested in alternative RNA structures and ...

Detailed map of the spliceosome is being made publicly available to help researchers pinpoint exactly where splicing errors ...

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...

RNA可变剪接 (Alternative ...

“Our study shows the potential of RNA editing to develop gene therapies that offer an alternative treatment to the invasive, frequent eye injections that are currently used to treat wet macular ...

Apr. 30, 2024 — A genetic propensity to higher circulating levels of lipids containing arachidonic acid, an omega-6 polyunsaturated fatty acid found in eggs, poultry, and seafood, has been found ...

THRAP3, STMN1, and GNA13—are overrepresented in blood cancers like acute myeloid leukemia (AML) and could prove to be novel ...