Goldstein and his colleagues studied the role of amyloid precursor protein (APP), which gives rise to the abnormal ... When something goes wrong with this transport process, the cell often cannot cope ...

“Current approved therapies for ATTR target precursor protein production, reducing the formation of new amyloid, but there is a significant unmet need for new therapies that can remove the existing ...

A new review was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), on ...

which hinges on the premise that abnormal processing of a protein called amyloid precursor protein and accumulation of its byproduct, called beta-amyloid, causes Alzheimer's. Notably, drugs that ...

Amyloid beta (Aβ) peptide, a 40-42 amino acid protein cleaved from the amyloid precursor protein (APP ... whether Aβ is part of the biochemical process that causes the loss of function ...