This manuscript provides fundamental studies to help us better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP).

A new review was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), on October 29, 2024, Volume 16, Issue 20, titled, "Brain aging and Alzheimer's ...

In contrast, these tangles are rare in non-human primates and typically confined to small regions of the brain. Clumps of ...

In this potentially valuable computational study, the authors conducted atomistic and coarse-grained simulations to probe the temperature-dependent phase behaviors of ELF3, a disordered component of ...

10Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark. 11Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Search for other works by this author on: 3Penn ...

While there’s no cure, treatment can help slow progression. Amyloidosis occurs when amyloid proteins buildup in the body. Several types of amyloid proteins can build up, resulting in different ...

and fragment specifying whether the structure originated from a fragment screen (Yes) or not (No) (PTP1B) (CSV) Table file describing MPro structure files used in this analysis, with the following ...

Poly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its activity – poly(ADP-ribosyl ... Functionally, ...

Diagnosis and monitoring of sporadic Alzheimer's disease (AD) have long depended on clinical examination of individuals with end-stage disease. However, upcoming anti-AD therapies are optimally ...

Many of these treatments aim to modify the disease process itself. One of the hallmarks of Alzheimer’s disease is protein plaques that form between brain cells, made of beta-amyloid fragments. These ...