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The drugs attack so-called amyloid plaques in the brain. But how can we reliably and cost effectively diagnose the presence of amyloid plaques in patients who show up at memory clinics with slight ...

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Amyloid fibrils appear in ... that rub shoulders in the packed fibril structure. When the group mutated any of these three amino acids in purified protein experiments, the mutant synucleins ...

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This manuscript provides fundamental studies to help us better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP).