Hepatitis B virus (HBV) has a narrow host range, mainly infecting hominoids. A new study reveals the structural differences in the liver cell receptor (NTCP) between humans and monkeys, explaining why ...
A study reveals why monkeys resist HBV infection, showing that specific amino acid differences in their NTCP receptor prevent ...
In hepatocytes, bile acids are secreted into bile canaliculi by bile salt export pump (BSEP), cholesterol is secreted by ATP binding cassette subfamily G member 5 (ABCG5) and ABCG8 heterodimer and ...
Odevixibat is a once-daily non-systemic ileal bile acid transport (IBAT) inhibitor approved under the brand name Bylvay ® in the U.S. as the first drug treatment option for patients 3 months of age ...
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Hepatitis B virus (HBV) infection is a leading cause of chronic liver diseases that spreads among individuals through blood ...
As well as having a role in lipid absorption, bile acids can act as endocrine-signaling molecules. With previous studies suggesting that bile acids operate as metabolic integrators, Watanabe et al.
Therefore, if a child presents in early infancy with cholestatic hepatitis with normal γGT, elevated serum bile acid concentrations (excluding bile acid synthesis defects) and without lymphoedema ...
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