OPG and RANKL Are Regulated by Systemic Hormones, Growth Factors, and Cytokines Cite this: Osteoprotegerin and its Ligand: A New Paradigm for Regulation of Osteoclastogenesis and Bone Resorption ...

Osteolytic diseases, such as osteoporosis, rheumatoid arthritis, osteosarcoma, and giant-cell tumors of bone, are characterized by increased bone resorption and decreased bone formation, leading to ...

“The average woman gains about six to seven pounds during this menopausal transitional period,” says Daniel H. Bessesen, MD, ...

Drugs used in osteoporosis treatment can be divided into two broad categories depending on their primary mode of action: antiresorptive drugs primarily inhibit osteoclastic bone resorption, with ...

Release of the drug from the bone mineral matrix requires bone resorption, and reduction in bone resorption is the primary mode of action of bisphosphonates. The terminal half-life of alendronate ...

At the recent SEC meeting for analgesics and rheumatology, the expert panel reviewed the proposed Phase I study protocol of ...

When bone resorption (breakdown) surpasses bone production, it occurs. Bone loss is accelerated after menopause due to the lack of estrogen, which is essential for maintaining bone density. The five ...

Diabetes creates high glucose concentration environments, which alter the osteoblasts allowing them limited abilities in growth, thus allowing imbalance in bone formation and resorption.