It seems that proteins called hypoxia-inducible factors (HIFs) can affect gene expression in low-oxygen conditions. While some control of gene expression is mediated through control of whether a ...

Franck Polleux (Columbia University, USA), these genes have been found to slow down synapse development when artificially introduced into mouse neurons of the cerebral cortex. The question of ...

Two control groups not exposed to hypoxia, but either 21% (C21, n=5) or 100% O2 (C100, n=8) for 30 min were used as comparison. GeneChip Mouse Gene ST 1.0 Arrays (Affymetrix) were used to analyze ...

Neurologist Christopher Walsh discovered genes that direct cerebral cortex development. We asked him what they reveal about intelligence, psychiatric disorders, and the nature of being human This ...

Franck Polleux (Columbia University, USA), these genes have been found to slow down synapse development when artificially introduced into mouse neurons of the cerebral cortex. The question if ...

Franck Polleux (Columbia University, U.S.), these genes have been found to slow down synapse development when artificially introduced into mouse neurons of the cerebral cortex. The question if ...

“The thinking at the time was that if we could figure out how the brain can switch itself off and then recover, and we could mimic that somehow with a drug or a gene therapy or ...

Although the brain circuitry involved in ADs has been identified, its link with gene expression remains unclear. Two ...

grown from human stem cells and transplanted into a mouse cerebral cortex. Two human-specific genes, SRGAP2B and SRGAP2C, were turned off, causing the neuron’s synapses to mature faster.

Through rigorous testing, the researchers identified several vectors that demonstrated enhanced brain delivery and minimized ...

At a median follow-up of 6 years after lentiviral gene therapy, most patients with early cerebral adrenoleukodystrophy and MRI abnormalities had no major functional disabilities. However ...