It is worth noting that in addition to TERT, the production of immune regulatory factors is also influenced by multiple issues. For example, Parish et al. observed that sustained CD28 expression ...

First generation CAR T cells only had a CD3 zeta chain and were not very effective. Second generation CAR T cells added an additional signaling domain, including CD28 or 4-1BB. Third generation CAR T ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The ubiquitin ligase FBXO38 does not regulate ...

The way the Linux file system is laid out makes perfect sense. I've been using Linux for so many years that I can't imagine another file system making more sense. When I consider how the Windows ...

Developed by a team of skilled programmers and AI enthusiasts, this powerful script aims to flatten the repository structure into a single file, thereby enhancing the AI’s comprehension of the ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. CD8 + T cells have critical roles in tumor ...

2024 年 ESMO 年会将于当地时间 9 月 13 日至 17 日在西班牙巴塞罗那召开。本次大会上，赛诺菲首次公布了其 CD3 X CD28 X HER2 三抗 SAR443216 治疗晚期实体瘤的 1 期临床数据。 Insight 数据库显示，SAR443216 曾是全球首个进入临床阶段的 CD3 X CD28 X HER2 三抗。在 2023年 Q4 财报 ...

Through the analysis of an innovative bamboo grid structure created using augmented reality by architects Kristof Crolla and Garvin Goepel in August 2023, we delve into the intricate world of ...

T cell activation requires engagement of a cognate antigen by the T cell receptor (TCR) and the co-stimulatory signal of CD28. Both TCR and CD28 aggregate into clusters at the plasma membrane of ...

The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged. Here, we show that ‘axis ...