MDNA11 is a next-generation IL-2 superkine designed to selectively stimulate effector immune cells (CD8 + T cells and NK cells) by enhancing affinity for IL-2Rβ (CD122) while avoiding IL-2Rα (CD25), ...

Calcium signalling is an essential feature of T cell activation. Here authors employ ... of the inhibitory receptor NKG2A on tumor-reactive CD8 cytotoxic lymphocytes. The therapeutic success ...

Their study, published in Oncogene, explores how increased methylmalonic acid impairs the activation and effector functions of CD8+ T cells, immune cells that play a vital role in fighting cancer.

T cells are a type of white blood cell that is central to your immune defense. There are four types which serve different functions: This article will guide you through how CD4 and CD8 cells interact, ...

A new study has found a surprising link between high levels of methylmalonic acid and the weakening of CD8+ T cells, shedding light on potential pathways through which aging may promote lung cancer ...

Combining the molecular signatures with immunophenotypic profiles revealed that cytotoxic CD8 ­T cells­ were associated with SGS. Further, we observed the activation of SGS in cytotoxic CD8 T cells ...

Immunotherapy, which enhances the immune system's T cell response to eliminate cancer cells, has emerged as a key approach in ...

Thus, the purpose of these studies was to test the hypothesis that the adipokine chemerin promotes CD4 and CD8 T cell activation and cytokine secretion. To test this hypothesis, primary mouse ...

Moreover, in people with MS and subclinical neuroinflammation, CD8 + T cells in the peripheral blood and cerebrospinal fluid expressed genes associated with increased activation, antigen ...

Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...

Equillium Inc. (Nasdaq: EQ), a clinical-stage biotechnology company leveraging a deep understanding of immunobiology to ...