Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells. In this immunofluorescence image, a group of killer T cells (outer three) is engaging a cancer ...

26 in Nature Immunology, the researchers discovered that activating a metabolic pathway called the pentose phosphate pathway makes antitumor CD8 T cells more likely to stay in an immature ...

Here we dissect the heterogeneity in metastasis-associated astrocytes using scRNAseq and report a population that blocks the antitumoral activity of infiltrating T cells. This pro-tumoral activity is ...

The extensive immunosuppressive microenvironment prevalent in hepatocellular carcinoma (HCC) has constrained the effectiveness of T-cell therapies. Adenylate cyclase 7 (ADCY7), a transmembrane protein ...

Antigen-presenting cell and T-cell trafficking following skin transplantation. At 3–4 days following placement of skin allografts, when the blood and lymphatic circulation is restored ...

This valuable study reports on a novel role of PD-1 in early T cell differentiation, showing that PD-1 stimulation impairs Th2 differentiation more effectively than that of Th1, with implications for ...

CAR T-cell therapy is a type of immunotherapy. CAR stands for chimeric antigen receptor. You might also hear it called a type of adoptive cell transfer. CAR T-cell therapy is a very complex and ...

Abs to stain for MDSCs were CD11b-APC (clone M1/70; BD Biosciences), Ly6G-FITC (clone 1A8; BD Biosciences) and Ly6C-PE (clone AL-21; BD Biosciences). For T-cell activation markers, cells were stained ...

Intrahepatic ALGS-like pericellular fibrosis is recapitulated by Jag1 Ndr/Ndr mice. Single-cell transcriptomics and flow cytometry identified dysregulation of maturing hepatocytes and T cells during ...