Cancer immunotherapy strategy equips T cells with molecular GPS that lets them home in on brain tumors and sites of ...

The steady accumulation of knowledge about the multifarious roles of glial cells, in both healthy and diseased states, has greatly added to the complexity of our picture of the CNS. However ...

Astrocytes are star-shaped glial cells in the central nervous system that support neuronal function, maintain the blood-brain ...

为了设计能够特异性靶向中枢神经系统（CNS）的细胞，我们鉴定了细胞外中枢神经系统特异性抗原，包括中枢神经系统细胞外基质的成分和在神经元或胶质细胞上表达的表面分子。 用于检测这些抗原的合成Notch受体被用于编程改造T细胞，仅在大脑中诱导不同有效载荷的表达。诱导嵌合抗原受体表达的CNS靶向T细胞有效清除了原发性和继发性脑肿瘤，而不损害脑外交叉反应细胞。 此外，局部递送免疫抑制细胞因子白介素—10的中 ...

A unique combination of explainable AI and repurposing animal camouflage detection algorithms can identify human brain cancer ...

The Deneen Lab seeks to unlock the enigmatic biology surrounding glial cell development and function in the brain. Beginning with developmental gliogenesis, we identified the key transcriptional ...

2 The CNS is made up of neurons and glial cells, with the latter group—including astrocytes, oligodendrocytes, and microglia—exhibiting greater diversity and function than neurons. Once ...

Both space exploration and stem cells have been at the center of major research projects, and combining the two has led to a ...

The increasing implication of glial cells in neurodegenerative diseases makes them an appealing addition to iPSC-based model systems for investigating disease mechanisms. Over the last decade, Dr.

Unlike other organs that have fat cells, neurons and other cells in the central nervous system (CNS ... a study investigating ...