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Nature | 肿瘤“隐身术”背后真相:GDF-15成免疫治疗新靶点
引言近年来,免疫治疗以其激活人体免疫系统对抗癌症的创新机制,掀起了肿瘤治疗的革命性浪潮。其中,针对程序性死亡蛋白1(PD-1)和其配体PD-L1的免疫检查点抑制剂成为了多种癌症的一线治疗方案。然而,尽管它们取得了令人瞩目的成效,但疗效有限的问题仍难以 ...
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