The host senses the presence of microorganisms using receptors that are specialized for the recognition of microbial components, which are chemically distinct from the host's endogenous molecules.

The principle behind this therapy is that the overexpression of receptors on the surface of tumor cells and various signaling pathways associated with viral clearance enable OV to enter tumor cells ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In the early phase of Alzheimer’s disease, ...

Objectives Antitumour necrosis factor (TNF) therapy has revolutionised treatment of several chronic inflammatory diseases, including spondyloarthritis (SpA). However, TNF inhibitors (TNFi) are not ...

The cytokines analyzed included IL1α, IL1β, IL6, IL8, TNFα, CXCL10, CCL2, CCL3, CCL4, IL10. mRNA expression analysis by quantitative RT-PCR mRNA expression was quantitated using quantitative reverse ...

Receptor activator nuclear factor kappa B ligand (RANKL ... Macrophages were also found to be the main source of APRIL, CCL2, CCL3 and VEGF-α mRNA expression in RA synovial fluid, confirming their ...

睡眠对心血管健康至关重要。然而，连接心血管病理和睡眠的回路尚不清楚。目前还不清楚心脏损伤是否会影响睡眠，以及 ...