Another important approach will be to exploit ongoing genome projects to try to identify all the genes required for the cell cycle. Comparison of the budding and fission yeast genome sequences ...

Cytokinesis is a key event in the cell cycle requiring tight coordination of mitotic spindle assembly, actomyosin contractility and membrane dynamics, but the mechanisms that regulate cytokinesis are ...

This led to the identification of SAR020106 as a potent and selective inhibitor of CHK1 with in vivo activity in human tumour xenograft models and provided proof of both mechanism and concept for the ...

Several tumour-suppressor proteins monitor intrinsic and extrinsic signals and integrate these inputs to decide whether the cell should remain in a quiescent state or enter into the cycle of ...