1Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

近日，德国癌症研究中心（DKFZ）、欧洲分子生物学实验室（EMBL）等机构的研究人员对8名CK-AML患者的10份样本进行了单细胞多组学分析，深入研究了CK-AML的遗传复杂性和结构异质性。

Chromosomal instability plays a crucial role in the progression of cancer: it shapes the properties of tumor cells and drives ...

Cannabis exposure leads to genetic damage and accelerated aging, raising concerns about its transgenerational health effects ...

Research indicates that cannabis use causes cellular damage that increases the risk of highly cancerous tumors by disrupting ...

The researchers found that stratification of patients with T-ALL into low- or high-risk of relapse could be achieved using 15 genomic imbalances as a threshold. Whole-genome analysis (WGA) identified ...

Scientists from the German Cancer Research Center (DKFZ), the Heidelberg Stem Cell Institute HI-STEM and the European ...

Experts call this chaotic condition chromosomal instability, or "chromothripsis." The prognosis for those affected is significantly worse than for AML patients with normal chromosome sets ...

Recent studies highlight the role of reactive oxygen species (ROS) in inducing chromosomal damage and genomic instability through mechanisms such as micronuclear rupture and chromothripsis ...

Alterations in genes such as CDKN2A, DEPDC5, RB1, and DMD are more frequent in advanced GISTs, and massive genomic rearrangement events like chromothripsis and kataegis contribute to tumor ...