The crystal structure of a second G protein–coupled receptor sheds light on these key pharmaceutical targets. In contrast, β2AR and essentially all of the other GPCRs are present at very low ...

In the end, what will be required to truly attain the grail is the crystal structure of a GPCR in complex with a heterotrimeric G protein, as this would most clearly delineate the features of a ...

including in structure-based drug design. Drago began exploring a technique to pinpoint otherwise elusive hydrogens that ...

Prof. Leslie Leiserowitz first became intrigued by malaria when he was a young boy in South Africa. His father, who scouted ...

well ordered protein crystals in microgravity for highly medically relevant proteins that are difficult to crystallize in 1-g. From these crystals, molecular structures will be obtained and new drugs ...

Researchers at New York University have devised a mathematical approach to predict the structures of crystals—a critical step in developing many medicines and electronic devices—in a matter of ...

Researchers report detailed structural and atomic information for glassy and liquid magnesium silicates, which are important ...

WNKs sense osmotic pressure by binding specific water molecules to the inactive dimeric configuration of WNK1 and WNK3, integrating signals with chloride inhibition as demonstrated by mutagenesis and ...

Space-grown crystals could lead to targeted cancer drugsResearchers used space-grown protein crystals to determine the ...

After translation, the polypeptide is finally folded into the correct shape and becomes a protein. Peptide bonds form between the adjacent amino acids to finalise the structure.