Transcription activation of genes by estrogens is driven by enhancers, which are often located within the same Topologically Associating Domain (TAD) as non-targeted promoters. We investigated how ...

Circle Pharma, a clinical-stage biopharmaceutical company dedicated to discovering and developing a new generation of macrocycle therapies, today announced that preclinical data from its lead ...

In biochemical and cellular studies, Circle Pharma’s cyclin A/B RxL inhibitors have been shown ... Circle Pharma’s MXMO™ platform combines structure-based rational drug design and advanced ...

About CID-078, Circle Pharma’s Cyclin A/B RxL Inhibitor Program CID-078 is ... Circle Pharma’s MXMO™ platform combines structure-based rational drug design and advanced synthetic chemistry ...

Kornfeld; Fredric E. Wondisford; Mehboob A. Hussain siRNA transfection achieved ∼40% knockdown of cyclin A2 protein(Fig. 5). This resulted in a significantly reduced Min6 proliferation rate (1. ...

TCR-peptide–MHC (pMHC) class I complexes for which crystal structures have been determined (mouse 2, 2C–dEV8–H-2K b, human 3,4 ... on solving the crystal structure of a mouse TCR in complex ...

Barnard b is a terrestrial exoplanet that orbits a M-type star. Its mass is 0.37 Earths, it takes 3.2 days to complete one orbit of its star, and is 0.02294 AU from its star. Its discovery was ...