CDK2 and Cyclin ... degradation, and key downstream pharmacodynamic markers including CD69, IL-2, IL-6, and IL-17. Submit an IND application for MRT-8102 in H1 2025. Nominate a CDK2 program ...

This valuable study uses robust time-dependent microscopy assays to show that during HIV-1 infection, the viral accessory protein Vif causes cell cycle arrest during metaphase and not G2/M as ...

Within specific indications, CID-078 single agent activity was correlated with RB1 mutation, high E2F target, or G2M checkpoint hallmark pathway scores ... with dual cyclin A and B RxL inhibitory ...

Get article recommendations from ACS based on references in your Mendeley library. Pair your accounts. Export articles to Mendeley Get article recommendations from ACS based on references in your ...

They examined how MZ1 was able to hold onto target protein Brd4 BD2 and direct it toward UBE2R1, a member of the ubiquitin-conjugating enzyme family, demonstrating the proficiency of MZ1 to position ...

Career readiness—and especially the somewhat amorphous concept of career pathways—has gained momentum over the past several years ... The Comprehensive Local Needs Assessment required by the Carl D.