Cyclin-dependent kinases (CDKs ... lack at least one of the conserved catalytic residues 2 and may not have kinase activity. Kinase activity has not been detected for several CDK-related proteins ...

Investigators from the University of Michigan and affiliated organizations published data from a study that aimed to investigate the role of cyclin-dependent kinase 12 (CDK12) in prostate cancer (PCa) ...

隶属细胞周期蛋白依赖性激酶（Cyclin-dependent kinases, CDKs）的CDK8和CDK19通过调节信号诱导的特异性转录重编程，在细胞增殖和分化过程中发挥关键作用。

Inotuzumab Ozogamicin and Low-Intensity Chemotherapy in Older Patients With Newly Diagnosed CD22+ Philadelphia Chromosome–Negative B-Cell Precursor Acute Lymphoblastic Leukemia We enrolled 16 patients ...

CDK4–cyclin D1, CDK5–p35, His-tagged Erk1 and Erk2, protein kinase C isoforms, the catalytic subunit of cAPK, cGMP-dependent protein kinase, casein kinases 1 and 2, the insulin-receptor ...

Novartis NVS announced that the Committee for Medicinal Products for Human Use (“CHMP”) of the European Medicines Agency (EMA ...

The Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) has approved the ...

Title: INX-315, an oral, potent and selective CDK2 inhibitor in patients with CDK4/6 inhibitor resistant ER+/HER2- breast cancer or CCNE1 amplified solid tumors: phase 1 monotherapy dose escalation ...

Disease progression in metastatic breast cancer is a challenge that no single entity can solve alone. Breakthroughs in ...

Image Credit: Kateryna Kon/Shutterstock.com In a recent study published in Cell Reports Medicine, researchers investigated whether loss of the cyclin-dependent kinase 12 (CDK12) gene drives ...

Presented clinical data for multiple assets across modalities, including bispecific antibody candidate BNT327/PM8002 and mRNA cancer vaccine ...