Furthermore, the presence of PARP1 condensates significantly promotes DNA ligation upon PARylation. These findings provide insight into how PARP1 condensation and PARylation regulate the assembly and ...

Ethanol-precipitate the DNA before ligation to concentrate the sample and remove salts that can interfere with ligation. The amount of vector obtained is usually sufficient to perform two 260-ng ...

Neurobiology, Neurodegeneration and Repair Laboratory, National Eye Institute, National Institutes of Health, Bethesda, United States This important study employed multiple orthogonal techniques and ...

Gene therapy can effectively treat various diseases, but for some debilitating conditions like muscular dystrophies there is a big problem: size.

Nov. 19, 2024 — Leveraging a unique statistical analysis and applying it to ancient DNA extracted from human skeletal remains, a team of researchers has revealed new insights into how ancient ...

StitchR, a new gene therapy technique, delivers large genes in two parts to treat muscular dystrophies by restoring critical proteins in animal models.

1Center for Personal Dynamic Regulomes, Stanford University, Stanford, California.

Gene therapy can effectively treat various diseases, but for some debilitating conditions like muscular dystrophies there is ...

How Dog DNA Kits Work All the kits we tried have the same basics. After you register the kit, take a swab or two of the inside of the cheek pouch of your doggie. Do this a couple of hours after ...