Bitter taste receptor has hidden intracellular pocket that enables activation via simultaneous extracellular/intracellular ...

A new study describes an exciting discovery that changes the way we understand human bitter taste receptors. The research has ...

"Tasting Upside-Down - An Unusual Sensing Mechanism was Found in Human Bitter Sensing" A new study revealed that some bitter ...

Immunolabelling showed specific colocalisation of receptors with EEC mediators PYY and GLP-1 (L-cells) or 5-HT (enterochromaffin cells). We exposed isolated proximal colonic mucosa to specific ...

This valuable study proposes a novel rapid-entry mechanism of S. aureus that involves the rapid release of calcium from lysosomes. The strength of the paper lies in a very interesting hypothesis; what ...

Scientists examine the effectiveness of an antibody targeting cell adhesion molecule 1 in alleviating pain-induced neuronal ...

In the latter instance, cells can be genetically modified to express chimeric antigen receptors (CARs) to target cancer cells ...

Adenosine and various adenosine receptor ligands acting at adenosine A 1 and A 2A receptors have been explored in several experimental models of drug addiction. The therapeutic effects of the ...

Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...