A protein has many identities and one of them depends on the arrangement of its amino acids in the three dimensions of space — in other words, its 3D structure. And scientists have spent decades ...
Protein folding is the process by which proteins achieve their mature functional (native) tertiary structure, and often begins co-translationally. Protein folding requires chaperones and often ...
Briola and co-authors determined the structure of the human CTF18 clamp loader bound to PCNA to high resolution, analyzed the structure, and tested a new mechanism involving a human-specific Ctf18 ...
New research has detailed how UNC45, a protein chaperone, distinguishes between healthy and faulty myosin in muscle cells, guiding them to either proper assembly or degradation. Chaperones are ...