Pancreatic cancer is the fourth leading cause of cancer death in the US, with over 35,000 deaths reported in 2009. 1 In 1997, gemcitabine became the standard of care for advanced disease and since ...

Results from a randomized, phase 2 clinical trial show that adding high-dose, intravenous (IV) vitamin C to chemotherapy ...

The molecular basis and mechanisms of action of combining classic cytotoxic agents (e.g. platinum-containing drugs, taxanes, etc.) and novel agents (e.g. tirapazamine, EGFR inhibitors and other ...

Here, we review the mechanism(s) of action of erlotinib ... line carboplatin–paclitaxel (TRIBUTE trial) or cisplatin–gemcitabine (TALENT trial). Erlotinib in a Phase III, randomized, placebo ...

Topline data from Phase 2 CM24 pancreatic cancer trial expected by the end of 2024New CM24 biomarkers data presented during the third quarter of ...

Mechanism of action describes the process by which a molecule, such as a drug, functions to produce a pharmacological effect. A drug’s mechanism of action may refer to its effects on a ...

Ancient civilizations pioneered early versions of contemporary mechanisms, offering valuable insights into the origins of modern technology. An astrolabe. Credit: Anders Sandberg / Flickr / CC-BY-2.0 ...

A technological breakthrough by medical researchers at Tel Aviv University enabled the discovery of a cancer mechanism that prevents the immune system from attacking tumors. The researchers were ...

The mechanisms underlying skin renewal are still poorly understood. Interleukin-38 (IL-38), a protein involved in regulating inflammatory responses, could be a game changer. A team from the ...

A randomized, phase 2 clinical trial shows that adding high-dose, intravenous (IV) vitamin C to chemotherapy doubles the overall survival of patients with late-stage metastatic pancreatic cancer from ...