On the contrary, there is minimal expression of class I HLA antigens on hepatocytes, which favors decreased antigenicity. It is also thought that donor Kupffer cells may be replaced with host ...

and resident Kupffer cells (blue) and from injured hepatocytes (green). Oxidative stress, cytokine release, endotoxin, and ethanol and its metabolites can stimulate paracrine chemokine secretion ...

They can, however, also infect other organs and cause neurological disorders. Little is yet known about how this process works. A research team has now developed a cell model to study the ...

2019). Periodontal bacteria and their virulence factors may reach the liver via the damaged gut and act directly on hepatocytes, Kupffer cells and hepatic stellate cells (HSCs) through activation of ...

Nov. 13, 2024 — A research team reported recently that heart muscle cells grown from induced pluripotent stem cells can integrate into the hearts of monkeys with a state of pressure ...

Stem cells are cells that have the capacity to self-renew by dividing and to develop into more mature, specialised cells. Stem cells can be unipotent, multipotent, pluripotent or totipotent ...

eLife is a non-profit organisation inspired by research funders and led by scientists. Our mission is to help scientists accelerate discovery by operating a platform for research communication that ...

Accumulation of extracellular matrix (ECM) in liver fibrosis is associated with changes in protein abundance and composition depending upon etiology of the underlying liver disease. Current efforts to ...

Pluripotent stem cells are cells that have the capacity to self-renew by dividing and to develop into the three primary germ cell layers of the early embryo and therefore into all cells of the ...