Epigenetic modifications, particularly histone modifications, play a crucial role in cancer initiation and progression. These modifications, which include methylation, acetylation, phosphorylation, ...
Mechanistically, ANK deficiency in VSMCs caused abnormal cytosolic accumulation of citrate, which was cleaved into acetyl coenzyme A and thus intensified histone acetylation at H3K23, H3K27, and H4K5.
are known to induce the EBV lytic cycle by promoting histone acetylation. The study findings, however, show that C210 activates the EBV lytic cycle by inhibiting HSP90 function and upregulating ...
This work will be of high interest to a broad swathe of scientists studying native macromolecules present at low concentrations in cells. Cryo-EM single-particle analyses typically require target ...
This study presents important findings on the role of CXXC-finger protein 1 in regulatory T cell gene regulation and function. The evidence supporting the authors' claims is solid, with mostly ...