Here, interleukin (IL)-6-mediated STAT signalling was investigated in circulating lymphocytes of an independent early arthritis patient cohort, seeking further insight into RA pathogenesis and ...

Our findings identify the IL-6–Yap–Snail signalling axis as a fibroblast-specific therapeutic target in RA synovitis. Altogether, these data show extensive proliferation and expansion of ...

Belgian biopharma company UCB is bringing up the rear of the IL-17 inhibitor category with its bimekizumab drug, so is celebrating new late-stage data showing superiority to the class leader.

Of particular interest is the emerging evidence highlighting the significant involvement of the JNK signaling pathway in these fundamental biological processes of IDD. This paper explores the ...

UCB has been bringing up the rear in the IL-17 inhibitor category with bimekizumab, but now has EU approval for the drug and thinks it can mount a stiff challenge to the leaders, including ...

22 Nebraska Cornhuskers and No. 24 Illinois Fighting Illini are deadlocked in a battle at Memorial Stadium Friday night, as the Huskers lead the Illini 17-10 at halftime. Nebraska has been able to ...

Here, we demonstrate that acidity restricts T-cell expansion mainly through impairing IL-2 responsiveness, lowers cytokine secretion upon re-activation, and reduces the cytolytic capacity of CD8 + T ...

NCST_FG Vinesett 37, 4:55. NIU_Thompson 6 pass from Hampton (Woodill kick), 1:45. RUSHING_N. Illinois, Brown 28-114, G.Williams 5-19, Lampe 2-6, Hampton 9-(minus 15). NC State, Waters 8-23 ...

These M2-type macrophages inhibit anti-tumor immune responses and promote tumor growth and metastasis by secreting a variety of immunosuppressive factors (e.g., IL-10, TGF-β) and factors that promote ...