Amidst the wide variety of glycan modifications that are carried out in the Golgi apparatus, the addition of mannose 6-phosphate (M6P) to the N-linked glycans of lysosome-resident hydrolase enzymes ...

接下来，研究团队进行了体内验证，在携带人类肿瘤的小鼠体内，SNIPR-CAR-T细胞能够特异性地靶向并攻击肿瘤，在没有引起CAR-T细胞疗法常见的副作用（例如体重减轻、器官损伤）的情况下显著缩小了肿瘤，最大限度地减少对健康组织的损伤。

Researchers developed SNIPRs, innovative receptors that sense soluble ligands, enabling precise therapeutic control in CAR ...

That led them to develop new receptors, now called SNIPRs (synthetic intramembrane proteolysis receptors), which can bind to soluble, or free-floating, molecules in the environment around a cell. The ...

That led them to develop new receptors, now called SNIPRs (synthetic intramembrane proteolysis receptors), which can bind to soluble, or free-floating, molecules in the environment around a cell. The ...

Laboratory of Chemical Biology, Department of Cellular and Molecular Medicine, KU Leuven − University of Leuven, Herestraat 49 box 901b, 3000 Leuven, Belgium ...

These reporters provide a new powerful tool for elucidation of the ubiquitin/proteasome pathway and for high throughput screening of compounds that selectively modify proteolysis in vivo.

One of the main obstacles to understanding how the brain works is that we know relatively little about how its nerve cells or neurons are connected to one another. These connections make up the ...