Signal transduction across membranes through regulated intramembrane proteolysis is conserved throughout all domains of life. In the SREBP pathway of human cells, the membrane-bound SREBP ...

Researchers developed SNIPRs, innovative receptors that sense soluble ligands, enabling precise therapeutic control in CAR ...

Postdoctoral fellow positions are available in the Laboratory of Biochemistry and Molecular Pharmacology at Memorial Sloan Kettering Cancer Center (MSKCC) to study regulated intramembrane proteolysis, ...

A member of the intramembrane protease family of specialized ... Through a process called proteolysis, which needs water to ...