This manuscript provides fundamental studies to help us better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP).

A plasmid DNA (pDNA) template is used as the ... template generation After aligning on a strategy for DNA production, a linearized DNA template is generated as the starting material for the ...

This important study identifies a short amino acid sequence that, when fused in multimeric form to the amino termini of luminal ER proteins, initiates proteasomal degradation via the Hrd1 ER quality ...