Many studies of liver fibrosis consist of animal testing with various hepatotoxins. Although this method is often used, the model at which cirrhosis or extensive fibrosis becomes irreversible has ...

Liver fibrosis is scarring of the liver. It has many causes, including alcohol-induced damage, infections, and diseases that harm the liver. Inflammation and injury of the liver can lead to scarring, ...

Gene-editing therapies—techniques that modify DNA to treat or prevent disease—have the potential to transform the field of ...

Detailed criteria of liver fibrosis and cirrhosis are available in online supplementary materials ... 8–10 However, the permanent human immune responses and further development of cirrhosis need to be ...

intrahepatic fibrosis in Alagille syndrome (ALGS) differs from other cholestatic liver diseases. The way cell populations are affected by ALGS and interact to influence disease progression was ...

Liver fibrosis is the formation of tissue scars in the liver due to chronic inflammation and injury. Over time, fibrosis can impair liver function and may lead to cirrhosis or even liver cancer .

Liver fibrosis is the formation of tissue scars in the liver due to chronic inflammation and injury. Over time, fibrosis can impair liver function and may lead to cirrhosis or even liver cancer.

MAT2A/MAT2B induction is required for hepatic stellate cell activation and FOXM1 is implicated in liver inflammation and fibrosis, but whether they crosstalk in liver disease is unknown.

Results: Liver biopsies from patients with cardiogenic liver disease demonstrated increased liver fibrosis, macrophage aggregates ... Ongoing investigation of the interplay between macrophages and ...

Liver fibrosis is a group of diseases that seriously affect the health of the world’s population. Despite significant progress in understanding the mechanisms of liver fibrogenesis, the technologies ...

Apr. 15, 2024 — Innovative carbon beads reduce bad bacteria and inflammation in animal models, which are linked to liver cirrhosis and other serious health ... Mechanism of Action of the ...