Researchers developed novel genetic tools to trace, ablate, and manipulate p16^Ink4a+^ senescent cells, revealing their ...

School of Public Health, the Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, China Macrophage-myofibroblast ...

Macrophage-myofibroblast transformation (MMT) transforms macrophages into myofibroblasts in a specific inflammation or injury microenvironment. MMT is an essential biological process in ...

With no effective treatments beyond liver transplants for these patients, RTX001 presents a first-in-class potential solution. RTX001 is an engineered, pro-regenerative macrophage therapy that ...

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The company plans to use the Series B investment to advance the development of its macrophage therapies in inflammatory and ...

Liver fibrosis is scarring of the liver. It has many causes, including alcohol-induced damage, infections, and diseases that harm the liver. Inflammation and injury of the liver can lead to scarring, ...

Results: Liver biopsies from patients with cardiogenic liver disease demonstrated increased liver fibrosis, macrophage aggregates, and biliary metaplasia. The severity of biliary metaplasia was ...