1Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Republic of Korea. 2Immuno-Oncology Branch, Graduate School of Cancer Science ...

Thus, targeting microglial inflammatory signaling represents a promising therapeutic strategy for neurodegenerative diseases. Regulator of G protein Signaling 10 (RGS10) is highly expressed in ...

University of Washington-led research, published in 2023, discovered microglia in the brains of people with Alzheimer's disease were in a pre-inflammatory state more frequently, making them less ...

Microglial response: Apoe-deficient microglia exhibited clustering and a DAM-like response to amyloid pathology induced by astrocyte-secreted APOE. Astrocyte-derived APOE and microglia: ...

These cells demonstrated expression of microglia-enriched genes and showed typical microglial functions such as LPS-induced responses and phagocytosis. We then performed xenotransplantation of these ...

Furthermore, the modulatory effects of hiPSC-NSC-EVs on microglia in the hippocampus persisted 2 months post-EV treatment without impacting their phagocytosis function. Such effects were evidenced by ...